AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |
Back to Blog
Atc medical abbreviation2/22/2023 ![]() ![]() The HLA-A1, B8, DR3 haplotype, for instance, is associated with disease of acute onset and short duration ( 15). ![]() Furthermore, genetic factors may influence disease presentation and progression. Although early studies showed associations with class I alleles, it is the HLA class II alleles that have been most frequently reported to be associated with the presence of disease ( 14). A subset of patients has Löfgren's syndrome, which is characterized by the acute presentation of fever, erythema nodosum, bilateral hilar lymphadenopathy, and polyarthralgia ( 9).įamilial clustering in sarcoidosis ( 10, 11) has prompted a search for relevant genes in the human leukocyte antigen (HLA) region, an area that is key to the adaptive immune response ( 12, 13). Clinical onset and progression vary widely in sarcoidosis, ranging from benign, self-limited, and often asymptomatic disease to progressive pulmonary fibrosis leading to respiratory failure. The disease is thought to be triggered by unknown environmental antigens in genetically predisposed hosts ( 1– 8). Sarcoidosis is a multisystem disease of unknown origin that is characterized by the accumulation of mononuclear cells at disease sites resulting in granuloma formation. Further studies are needed to understand the molecular mechanisms underlying this association. In conclusion, this report describes a strong association between CCR2-haplotype 2 and Löfgren's syndrome. The association between CCR2-haplotype 2 carriage frequency and Löfgren's syndrome (odds ratio, 4.4 p < 0.0001) remained significant after adjustment for human leukocyte antigen haplotype DRB1*0301-DQB1*0201 (odds ratio, 11.5 p < 0.0001) and female sex (odds ratio, 3.2 p = 0.003), two known risk factors for Löfgren's syndrome. 38% respectively, p < 0.0001), whereas no difference was found between non-Löfgren sarcoidosis and control subjects (both 38%). In patients with Löfgren's syndrome, a strongly significant increase in the frequency of CCR2-haplotype 2, which includes four unique alleles (A at nucleotide position –6752, A at 3,000, T at 3,547, and T at 4,385), was observed compared with control subjects (74% vs. From the investigated CCR2 polymorphisms, nine haplotypes were deduced (haplotypes 1–9). Eight single-nucleotide polymorphisms in CCR2 were studied in a total of 304 Dutch individuals (90 non-Löfgren sarcoidosis, 47 Löfgren's syndrome, 167 control subjects). We hypothesized that sarcoidosis, or one of the disease subsets, could be associated with single nucleotide polymorphisms of C-C chemokine receptor 2 (CCR2) gene. Sarcoidosis is thought to result from the interaction between an unknown environmental antigenic trigger and the host's genetic susceptibility. ![]()
0 Comments
Read More
Leave a Reply. |